Thomas De Quincey, infamous for his memoir Confessions of an English Opium-Eater, is the major suspect in a series of ferocious mass murders identical to ones that terrorized London 43 years earlier. The blueprint for the killings seems to be De Quincey's essay "On Murder Considered as One of the Fine Arts." Desperate to clear his name but crippled by opium addiction, De Quincey is aided by his devoted daughter Emily and a pair of determined Scotland Yard detectives.