Jessica Fletcher’s British cousin, Emma MacGill, will be traveling to Edmonton in Alberta, Canada, to perform with international star Derek Braverman in an old-fashioned musical revue. Emma would love for Jessica to join her there and suggests she bring along some friends. Having just finished her latest book, Jessica is ready for a vacation and is delighted to agree. Dr. Seth Hazlitt and Sheriff Mort Metzger are huge fans of Braverman, so they are eager to tag along. Upon arrival in Edmonton, Jessica is quickly outed as mystery writer J. B. Fletcher, and despite numerous protests, a hotel staffer arranges a book signing for her. When a hotel bartender, who also happens to be a stagehand for Emma’s play, turns up dead backstage at the theater, Jessica’s fun and relaxing vacation quickly becomes anything but.

Evelyn Phillips, the former editor of the Cabot Cove Gazette, is back in Cabot Cove. Evelyn tells Jessica and Seth that she got a couple of really weird notes from Bertha Mae Cormier, so she’s come back to town to check on her old friend. Jessica does become somewhat concerned when Bertha Mae starts to talk about her new neighbor, Martin Terranova, who teaches yoga and meditation in his pool house. Jessica attends one of his classes and notices that Terranova is flirtatious with several elderly clients, especially Bertha Mae. Evelyn is becoming convinced that Terranova is after Bertha Mae’s money. A short while later, Martin turns up dead in his weight room. What at first blush seems to be an accident soon proves to be murder, and Evelyn becomes the prime suspect.

Jessica Fletcher is quick to accept an invitation to replace a speaker who couldn’t attend a book festival in Belfast, Ireland. When her Cabot Cove neighbor, Maeve O'Bannon, hears about the trip, she asks Jessica to deliver some paintings to her family in the village of Bushmills. Happy to extend her travels and see more of the Irish countryside, Jessica agrees. The festival goes off without a hitch, and it seems like Jessica is in for a relaxing vacation. But then Maeve’s cousin, Michael, is discovered dead under suspicious circumstances. Jessica finds herself once again in the midst of a murder investigation, and she’ll have to dig into the O'Bannon family’s secrets to unmask the killer.

Jessica Fletcher is delighted when her nephew, Grady, invites her to spend a few days with his family in an oceanside New York bungalow. She packs her bags and heads down to the city, ready to spend some quality time with Grady; his wife, Donna; and their young son, Frank. But the morning after Jessica’s arrival, Donna finds her boss dead on a tennis court, and Jessica’s dreams of a relaxing visit are quashed. Everyone in the small beachside community is a suspect, and the local authorities --- headed by an old colleague of Cabot Cove sheriff Mort Metzger --- have asked that no one leave town. Will Jessica be able find a killer and salvage the rest of her trip?

When Nelson Penzell, the co-owner of a local art and treasure store in Cabot Cove, is murdered, the nail tech from Jessica Fletcher's favorite beauty parlor is the main suspect. After all, she's the one who ran out of the store screaming, covered in blood and holding the murder weapon. Jessica is positive that Coreen can't possibly be guilty and is determined to prove it. When Michael Haggerty, a handsome MI-6 agent and Jessica's old friend, is caught snooping around the victim’s home, it's quickly apparent to her that she was right. Nelson has always had a bit of a reputation for being a rake, but Haggerty is sure his sins go far beyond what anyone in town imagined.

After traveling to Bethesda for a mystery writers’ conference, Jessica Fletcher decides she’s earned a vacation and takes a train to Columbia, South Carolina, to visit her old college friend Dolores, who has recently married her third husband, Willis Nickens, a wealthy and cutthroat businessman. They’ve moved into an opulent historic home with plenty of space for guests, and Jessica is ready for a week of shopping, gossiping and relaxing at the grand estate. But the morning after she arrives, Jessica discovers Willis face down in the koi pond, and despite what the police think, she’s sure foul play is involved. She hadn’t known Willis long, but it’s clear to her that he didn’t concern himself with making friends. The question isn’t if her friend’s husband was murdered but by whom.