Seventy-eight-year-old Harriet Chance impulsively sets sail on an ill-conceived Alaskan cruise that her late husband, Bernard, had planned. There, between the imagined appearances of Bernard and the very real arrival of her estranged daughter midway through the cruise, Harriet is forced to take a long look back, confronting the truth about pivotal events that changed the course of her life. In the process, she discovers that she’s been living the better part of that life under entirely false assumptions.
Having lost virtually everything, Benjamin Benjamin enrolls in a night class called The Fundamentals of Caregiving. He is assigned to 19-year-old Trevor, who is in the advanced stages of Duchenne muscular dystrophy. As the two embark on a wild road trip across the American West, a new camaraderie replaces the traditional boundary between patient and caregiver.