In Rome 1559, Sofonisba Anguissola is training to be one of the first female painters of the Renaissance. Under the tutelage of Michelangelo, she begins to stretch her talent to heights unheard of for a woman at the time. Her father places a lot of faith in her abilities and provides her with the best teachers, but her status as a woman means she cannot study, sketch, or paint the naked body. This leaves her with little understanding of the human form itself, and she is told it adds an inhibited quality to her work that she struggles to overcome.
During her time in Rome, she meets and falls in love with another student of Michelangelo’s, Tiberio Calcagni. T