Boston detective Jane Rizzoli is on the case of a big game hunter found dead in his apartment. Medical examiner Maura Isles connects the case to a number of seemingly unrelated deaths where the victims have all been found hanging upside down. Rizzoli ultimately uncovers the unsolved mystery of a deadly camping safari in Botswana four years prior. When she realizes the two cases are connected, Rizzoli must track down the sole survivor of the tragic trip to discover who --- or what --- is behind these gruesome deaths.