In 1873, a Cheyenne chief offers President Grant the opportunity to exchange 1,000 horses for 1,000 white women, in order to marry them with his warriors and create a lasting peace. These women, "recruited" by force in the penitentiaries and asylums of the country, gradually integrate the way of life of the Cheyenne, at the time when the great massacres of the tribes begin. After the battle of Little Big Horn, some female survivors decide to take up arms against the United States, which has stolen from the Native Americans their lands, their way of life, their culture and their history. This ghost tribe of rebellious women will soon go underground to wage an implacable battle, which will continue from generation to generation.

In 1873, Margaret Kelly participated in the U.S. government's "Brides for Indians" program, the conceit of which was that the way to peace between the United States and the Cheyenne Nation was for One Thousand White Women to be given as brides in exchange for 300 horses. These "brides" were mostly fallen women --- women in prison, prostitutes, the occasional adventurer, or those incarcerated in asylums. No one expected this program to work. And the brides themselves thought of it simply as a chance at freedom. But many of them fell in love with their Cheyenne spouses and had children with them...and became Cheyenne themselves.

ONE THOUSAND WHITE WOMEN is the story of May Dodd and a colorful assembly of pioneer women who, under the auspices of the U.S. government, travel to the western prairies in 1875 to intermarry among the Cheyenne Indians. The covert and controversial "Brides for Indians" program, launched by the administration of Ulysses S. Grant, is intended to help assimilate the Indians into the white man's world. Toward that end, May and her friends embark upon the adventure of their lifetime.